Speed and Convenience Aren't Everything with Diagnostics

نویسندگان

  • Virginia Barbour
  • Jocalyn Clark
  • Susan Jones
  • Melissa Norton
  • Paul Simpson
  • Emma Veitch
چکیده

In an age when we can sequence an entire genome within a day, we expect to be able to gather and access accurate information at a pace. After all, you didn't wait for this issue of PLoS Medicine to arrive in the post or trudge down to the library to read it; you accessed it instantly via the internet. Patients and clinicians also expect technology to provide similar speed when it comes to diagnosing infectious disease. Recent research and analysis published in PLoS Medicine reveals a theme of rapid diagnostics and raises the question of whether providing an answer quickly is enough to produce meaningful health outcomes. For patients suffering from any infectious disease, diagnosis should pave the way to treatment. Reducing the lag time between testing and diagnosis has obvious advantages for the patient by ensuring timely receipt of care, and this should in turn benefit others by reducing the probability of transmission. In December last year the World Health Organization (WHO) endorsed the use of a new automated PCR-based test for tuberculosis (TB), known as Xpert, which can rapidly confirm infection and detect resistance to rifampicin [1,2]. Many countries currently rely on sputum smear microscopy and culture to diagnose TB, which can take weeks to provide results. The new test takes under two hours to provide a diagnosis, fueling high hopes that it will transform TB diagnosis and therefore treatment. However, there is an additional cost associated with Xpert—each test cartridge currently costs approximately US$17 [3]—and despite being sold at reduced rates in countries where TB is endemic, question marks remain about whether it will be a cost-effective option in low-and middle-income settings. Since speed and convenience come at a cost, is that cost worthwhile? In a recent PLoS Medicine essay, David Dowdy and colleagues highlighted the challenges of determining the cost-effectiveness of rapid TB diagnostics, including the danger of draining resources from other TB-specific interventions and the need to take into account the cost of treating false-positive diagnoses [4]. WHO's recent policy recommendation against the use of rapid commercial serological tests for active TB serves as a stark reminder of the need to evaluate diagnostics fully [5]. The kits may be both rapid and convenient, but as a meta-analysis by Karen Steingart and colleagues in PLoS Medicine has shown, they fail in their primary purpose since they are neither accurate nor consistent enough to replace sputum smear …

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2011